Millennials ‘experimenting more in bed’

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Young people are taking part in a wider range of sexual practices, including anal sex, with opposite sex partners, research reveals.

Experts looked at responses to a national sex survey that has been carried out every 10 years since 1990 in the UK.

More than one in 10 millennial teenagers said they had tried anal sex by the age of 18.

By the age of 22 to 24, three in every 10 said they had tried it.

Vaginal and oral sex are still the most common types of sexual activity between young men and women, however.

The age that young people start having sex – vaginal, anal or oral – has not changed much in recent decades.

In the most recent survey, it was 16.

While the study in the Journal of Adolescent Health shows what types of sex people are having, it doesn’t shed light on why preferences are changing.

Experts can only speculate, but say society has become more accepting and less judgemental about sexual experimentation.

Breaking down taboos

Kaye Wellings, senior author and professor of sexual and reproductive health at the London School of Hygiene & Tropical Medicine, said: “The changes in practices we see here are consistent with the widening of other aspects of young people’s sexual experience, and are perhaps not surprising given the rapidly changing social context and the ever-increasing number of influences on sexual behaviour.”

Prof Cynthia Graham is a professor in sexual and reproductive health at the University of Southampton.

She said the internet and media might have played a role in breaking down sexual taboos.

“The internet means people can easily find and see things that they would not have been able to in the past.

“Anal sex is still pretty stigmatised, but attitudes appear to be changing. We know society has become more accepting of things like same sex behaviour overall. But there’s very little research out there about anal sex and motivation.”

She said more studies were needed to inform sex education and equip young people with the information they need for their sexual health.

Related Topics

Read more: http://www.bbc.co.uk/news/health-42051827

Kim Kardashian And North West Attend Katy Perry Concert On The Night Taylor Swift’s Album Drops

Don’t come for

Friday was, of course, the same day that Swift released a new album, and because it also happened to be the day Perry was performing at the Staples Center in downtown Los Angeles… And because this is apparently forever going to be a thing, Kim knew exactly what to do.

Legend!!! LOLz!!!

Here’s Kim, Katy, North, and the crew — which includes friend Larsa Pippen and her daughter along with some other kids — out backstage at Katy’s concert from last night (below):

Cute!!! And fun!!!

…But also always sending a message.

Kim’s been around the block with this stuff before, she knows how it’s done!

Ha!!!

[Image via Snapchat.]

Read more: http://perezhilton.com/2017-11-11-kim-kardashian-north-west-katy-perry-concert-los-angeles-backstage-meeting-snapchat

Old 10 note to disappear next year

Image copyright Nick Ansell/PA
Image caption The old £10 mote is soon to go the way of the old pound coin

If you still have any old £10 notes, make sure you spend them before 1 March next year.

The Bank of England has announced that the old paper notes, featuring naturalist Charles Darwin, will no longer be legal tender after that date.

Its days have been numbered since the new polymer tenner, depicting author Jane Austen, entered circulation in September.

But the old note can still be exchanged by the Bank after the cut-off date.

Threadneedle Street says polymer, also now used for the £5 note featuring Winston Churchill, is more durable and cleaner than paper notes.


Security features of Jane Austen £10 note:

  1. A see-through window featuring the Queen’s portrait
  2. Winchester Cathedral shown in gold foil on the front of the note and silver on the back
  3. A quill at the side of the window which changes from purple to orange
  4. A hologram which contains the word “Ten” and changes to “Pounds” when the note is tilted
  5. A hologram of the coronation crown which appears 3D and multi-coloured when the note is tilted
  6. Micro-lettering beneath the Queen’s portrait with tiny letters and numbers that are visible under a microscope
  7. A book-shaped copper foil patch which contains the letters JA
  8. The words “Bank of England” printed in intaglio (raised ink) along the top of the note

It has persevered with the material despite complaints from religious and vegan groups that the animal fat tallow is used in the production process.

Following consultation, the Bank said in August that it would continue with the use of tallow in future banknotes – saying it “has not taken this decision lightly”.

The Bank assessed whether palm oil or coconut oil should be used instead, but concluded that this might not be able to be sourced sustainably. Changing production would also involve considerable extra costs to taxpayers.

The old £10 notes have been in circulation since November 2000, but lost out to the new ones on grounds of security as well as durability.

The Jane Austen notes have a number of features built in that make them particularly hard to forge.

They also have an inscription in raised dots that helps blind and partially-sighted users to identify them.

The end of the old paper tenner follows the official withdrawal last month of the old round £1 coin, which has now been wholly replaced by the new 12-sided version.

Related Topics

Read more: http://www.bbc.co.uk/news/business-41974386

17 True Scary Stories That Will Ruin Your Night

Favi Santos

“I’m not your dad

“A girl I used to know told me a story that her ex husband used to wake up in the middle of the night because someone was tickling his feet. She told him her dad used to tickle her and her sisters feet to wake them up for school in the morning. So when weird things started happening around the house they would just say “knock it off dad” and it would stop. Well one day something happened in the kitchen (I don’t remember what) and she said “knock it off dad” and as she was walking out the door something growled in her ear “I’m not your dad”. They moved out a few weeks later.”

The man with the mustache

“When my son was about 3 he had a tent canopy attached to his bed frame. It covered about 3/4 of the length of his bed. He would always scoot towards the head of the bed and insisted covering up head to toe with his blanket, no matter how warm it was. I couldn’t turn off the lights until he was finished. I figured it was normal kid stuff. One night, just out of curiosity, I asked why he covered up so thoroughly. His response, “Because the man with the mustache won’t stop touching me. He’s always trying to tickle me. If I’m covered and way up here, he can’t reach me”. No one else had access to our house so needless to say, that scared the crap out of me. Till this day he still covers with his blanket, no matter how warm it is, although not as thoroughly as he used to. He doesn’t remember the man but still will not go to bed uncovered. He’s a teen now.”

Imaginary friend

“Ex-girlfriend moved into an apartment across the street from me, and told me her little brother had a new “imaginary friend” named Alex. Well I had been living in that neighborhood for about 5 years and 3 years prior to her moving in my neighbor Alex hung himself in that house.”

This is all very nope

“When I was a teenager in Colorado Springs we all used to crawl though this small tunnel that was directly under the interstate to get back and fourth from our neighborhood to the shitty trailer park with out obviously having to jump fences and run across the highway.

One drunken night alone I was on my way home about 2-3 am I came out of the tunnel only to find myself face to face with this huge rottweiler staring at me. I was in shock for a second, my stomach dropped. Instinctively I started yelling at the damn dog to go home. He just stood there glaring at me and every step I slowly took trying to get away he would bark and growl showing his teeth. So I started stomping towards him in a dominant way yelling at him to go on.

He turned and took steps back but still proceeded in torturing me barking and growling. I stupidity drunkenly started to power walk away. I then heard his feet running towards me as I had my back turned away from him. I turned back around only to see him lunging at me. I fell, when I turned and looked up the damn dog was completely out of sight as if I imagined the entire thing. To this day I don’t know if the dog was somebody’s pet or what. I didn’t hear him running away after I fell so I’ll never know I guess. Maybe he was a dark spirit.”

The thing

“When I was about 8 years old I was up in Maine at my uncle’s house with my cousin and little brother, all in the same age range. The part of Maine, Stratton, is pretty secluded about 30 minutes from Canada.

We were sleeping on sleeping bags in his living room, well all of the sudden through the window of my uncle’s door, probably about 9 feet tall, but had human like anatomy, this thing was standing hunched over looking into the house.

We all screamed and it did a non-human maneuver with it’s neck and ran behind the house. The footsteps of this thing practically shook the house. My mom and uncle come running into the living room. It’s been practically 20 years and we all still talk about it like it was yesterday.”

Spiders

“My friends father was a missionary in Africa. He was 16 and learning how to shave his face. 3 weeks went by and he woke up one morning with his throat extremely swollen. Flew him to the nearest hospital where the trauma surgeon took a scalpel…nicked my friends throat… and out spewed 100’s of tiny spiders….”

This is why I don’t work the late shift

“Was working midnights at a gas station. A couple came in trying to get behind the register. They went outside and left. I went in the bathroom and called the police. Who came as they were coming back in. They had bags, knives, a gun, rope, and various other weapons in the trunk. I don’t think they planned on me living. I was hiding in the bathroom when they were trying to come back in.”

Killer doll

“My pappy(grandfather) found a life size doll hanging by a rope around its neck, in a tree/wooded area on the way home one day. He said it looked like somebody hung it up there and was using it for shooting practice or something.

My mom was still a child so the jokester he is, brought it home for her and my Aunt. Well they actually liked the thing and cleaned it up and played with it. My grandmother says till this day the scariest things started to happen around their house.

ONE example: It was nighttime and her and my pappy were in bed sleeping. Well she said she woke up to the blanket making her feel strangled. And it was almost like someone crawled into their bed and laid in between them. She sat up, startled and that’s when their bed started to shake and dressers shaking also. But nothing on the dressers moved or fell. It got to the point she was so freaked out and fed up with all the spooky things going on in their house, she made my pappy get rid of it.

So he was good friends with the owner of a bar who was more than happy to take it off his hands. As he thought it would be a good conversational piece. Exactly one week later the man who the doll was given to died. Mind you he had perfect health.”

Final wishes

“On and episode of Beyond Belief like 7 years ago, I saw a true story about a step daughter who died She hated her step mother. And in death, they were both put in the same mausoleum. Every morning, the stone carcophagus’ were cracked and there was writing on the walls in blood begging for her to be away from the step mother even though the mausoleum was sealed every night… Still gives me chills to think about it.”

Dream boy

“This happened to me… I saw the ghost of a little boy run in front of my car and I almost crashed. That’s not the scary part tho. When I told my mom about it and where it happened, she told me of a dream she had when she was pregnant with me where she hit a little boy with her car on the same road at the same spot and when she got out to check on the boy, she said it was me.”

No curtains

“My husband and I had just moved into a new house in a new state with our then 3 year old. Naturally I needed to go food shopping for pretty much everything. It was dark by the time I arrived home and I could see, upstairs, in what is now our bedroom, (no curtains/blinds yet), what I was sure was my husband standing in the window. The light was on so it was pretty easy to see that he was standing there. I clearly needed help unloading so I went straight inside and upstairs only to find no one was up there. Came back down to find him on the other side of the house completely immersed in a video game, clearly had been there the whole time but I asked anyways and yup, hasn’t been upstairs since I left. Gave me the chills at the time, but more so after meeting our new neighbor who informed us the previous owner committed suicide inside our house. It was her (our neighbor’s) own late husband that discovered the body. Lots more stories, creepy but harmless, we still live in the house and have learned to coexist.”

Facebooking from beyond

“My friend’s friend died and a few days later the deceased was commenting on people’s fb post. People were spooked, angry, and confused. What it came down to was that it might have been something with his phone. He might have commented, loss service, passed away, phone was moved to a location with service, and then it posted. Still shocking.”

Grandma

“One night I hear my 6 yr old daughter talking to someone in her room. She was by herself. I asked her who she was talking to and she said “grandma ermmie”. Grandma Erma (only 2 people called her ermmie) died when she was 1. She never met her in person.”

Santa

“One Christmas, me and my son were at my parents house celebrating. It was getting late, i told my son, who was about five at the time, let’s get home and get you to bed before Santa goes to our house and has to leave because you’re not asleep. We get home, I’m getting our bags out of the car and my son says, mama!! Shhhh…Santa is in our house! My blood froze, our front curtains were open to show off our tree, so i asked what did you see? He said, Santa peeking at us in the window. I’m crapping my pants, i took him to my neighbors, and told them to call the cops if I’m not back in five minutes. The doors and windows were all locked and no sign of anybody in the house. I was scared all night.”

The dream

“One night I had a dream/nightmare? I was in a war. I went around the corner cause I was running from something. Came around the corner to see a gun pointed at my chest. It shot. With my left hand (this is important) I touched the wound and pulled my fingers away. There was blood on my 3 middle fingers to about the first knuckle line. I woke up in a dead sweat, calmed myself down it was only a dream, and went back to sleep. When I woke up however. I noticed there was something on my hand. My left hand. There was dried blood on my 3 middle fingers only down to the first knuckle. Of course I freaked out and immediately went to the full body mirror in the house. There wasn’t any other place that had dried blood.”

Trapped

“When I stayed at my grandparents house I was laying in bed and something came running down the hall. Everyone was asleep and the dogs were in the garage but whatever it was jumped on my bed, and since I had my head covered I never saw it, but it trapped me under my covers and I screamed and cried until I fell asleep.

I still have nightmares about it and that was close to 10+years ago.”

👻 You can read 101 of the scariest (and shortest!) true stories in our new collection, , available here. 👻

Read more: https://thoughtcatalog.com/erin-cossetta/2017/10/17-true-scary-stories-that-will-ruin-your-night/

‘Lack of humanity’: Dana Loesch unloads on nursing home staff who laughed as WWII veteran died

Horrific footage from 2014 was released this week showing how staff at a nursing home in ignored the dying pleas of a decorated WWII veteran.

The undercover video and depositions, which the Northeast Atlanta Health and Rehabilitation attempted to keep sealed, show how staff at the facility lied about their treatment of 89-year-old James Dempsey in the last moments of his life:

Read more: https://twitchy.com/gregp-3534/2017/11/15/lack-of-humanity-dana-loesch-unloads-on-nursing-home-staff-who-laughed-as-wwii-veteran-died/

Nine “Health” Foods That You’d Be Better Off Avoiding

Food-wise, it can be hard to keep up with what is healthy and what is not. When nutritionists decided that (healthy) fats, carbohydrates, and coffee weren’t so bad after all, we could all breathe a deep sigh of relief. But what about some of the so-called “health” foods that aren’t as good for you as they’re made out to be? Here are nine health fads that might be worth ditching. 

Fruit juices and smoothies

Freshly squeezed orange juice and a green smoothie straight from the Nutribullet – it’s fruit and vegetables so it must be good for you, right? From a nutritional standpoint, juices are a whole load better for you than your regular, sugar-laden fizzy drink. If it’s freshly squeezed, you get most of the vitamins, minerals, and phytonutrients from the whole fruit (and obviously that’s a good thing) but the juicing process removes almost all fiber, which is what keeps you feeling full. And because one glass of juice requires more than just one piece of fruit, you are drinking more sugar (a glass of orange juice has six teaspoons of sugar in, nearly the same as a can of full fat Coca-Cola) than you would likely consume had you stuck to one whole fruit. Smoothies aren’t so innocent either.

gokhancelem/Shutterstock

Granola

Granola tastes good but a lot of its innate deliciousness comes from sugar. It’s also high in carbs and calories but low in protein, and one portion of the “healthy” cereal is a lot smaller than you might imagine. A poll in the New York Times found that more than 70 percent of the public consider granola bars healthy but only 28 percent of nutritionists interviewed will back them up on this view. True, granola is high in fiber and nut varieties contain heart-healthy fats but, given its high sugar content, it might be best to start thinking of it as a dessert rather than a breakfast staple.

Fat-free or low-fat anything

If you’re trying to lose weight or eat healthy, swapping out your regular product for a lighter alternative sounds like a no-brainer. That is until you realize food manufacturers regularly add extra sugar or additives to make something fat-free edible, otherwise, it can be rather tasteless. Besides, the right fats in moderation are good for you. Think, avocados and oily fish, which can help protect you against cardiovascular disease, dementia, and different types of cancer. Sugar, on the other hand, can raise your risk of dying from heart disease. Experts reckon you should limit your intake to less than 10 percent of your daily calories.

joannawnuk/Shutterstock

Almond milk

Unless you’re dairy-free, buying almond milk instead of cow’s milk isn’t automatically healthier. In fact, it’s lower in protein and the food manufacturing process makes it harder for your body to absorb and retain all the nutrients. (Most vitamins are added in during the production process.) Besides, regular, dairy milk is full of important nutrients like vitamin A and B12, phosphorus, magnesium, zinc, and riboflavin. If you don’t have an intolerance and you’re not vegan, there’s no reason to avoid it.

Gluten-free

Massive caveat here – if you are part of the one percent who has celiac disease or a gluten-free intolerance, it’s best to stick to gluten-free alternatives. However, most people who profess to be gluten-sensitive probably aren’t. And foods that contain a gluten-free label aren’t inherently healthier. Some have even suggested they could be worse for you. They often contain added sugar and fat, and fewer nutrients. The verdict: unless you do have a real gluten intolerance, it’s not worth shelling out on gluten-free.

P-fotography/Shutterstock

Dried fruit

This one’s complicated. Dried fruit isn’t outright bad for you – in fact, it may contain more fiber and antioxidants called phenols than fresh fruit gram-for-gram. But it also contains more sugar and calories. Plus, you’re likely to tuck into a lot more fruit if you have it dried than you would had it been fresh. After all, when was the last time you ate four fresh apricots in a row? Dried apricots, on the other hand, are another story. Just something to keep in mind next time you grab a handful of banana chips or a bag of trail mix for your afternoon snack.

Agave nectar

Sorry, sugar is still sugar. It doesn’t matter that it’s labeled “natural” or “organic”, agave nectar and other “healthier” or “natural” sugars (looking at you honey and coconut sugar), are not that much better for you than the white, refined stuff. Agave has been declared a health food because of its low-glycemic index. This means you don’t get that sugar spike and subsequent crash. Instead of glucose, it has an extremely high fructose content. Fructose has been linked to all sorts of conditions, including heart disease, obesity, diabetes, and cancer.

Africa Studio/Shutterstock

Coconut oil

Coconut oil has been touted as a healthier alternative to other fats but this is false advertising, says the American Heart Association (AHA). It’s 82 percent saturated fats, which is far higher than either olive oil (14 percent) or your bog-standard chunk of butter (63 percent). Saturated fat raises your “bad” cholesterol levels and is linked to heart disease. Whereas 72 percent of the public thinks coconut oil is good for you, only 37 percent of nutritionists agree.

Vegetable chips

If you chose vegetable chips over the regular kind because it’s healthier, you might want to reconsider. Just like potato chips, they’re covered in salt and deep-fried. “Crisps [British for chips] are crisps, and even if they are made with vegetables, they are likely to contain too much in the way of fat, saturated fat and salt. In fact, the vegetable crisps here have higher levels of saturated fat and salt than some well-known, regular crisp brands,” Charlotte Sitling-Reed, a registered nutritionist, told The Independent.

Read more: http://www.iflscience.com/health-and-medicine/nine-health-foods-that-youd-be-better-off-avoiding/

What Every Parent Needs To Understand About Teens’ Mental Health

A new report is painting a bleak picture when it comes to teens’ mental health, as well as their access to professional support for those issues.

Data published by the nonprofit Mental Health America shows that rates of severe youth depression have increased from 5.9 percent to 8.2 percent over a five-year period. Half of those screened between the ages of 11 and 17 reported having thoughts of suicide or self-harm throughout the course of a week. South Dakota was the state that ranked the “best” in terms of good youth mental health. (The data measured access to treatment as well as prevalence of mental health conditions.) Nevada was ranked as the “worst” state.

Researchers collected public mental health data from each state between 2010 and 2015 (the most recent years of available information) to examine the state of mental health across the country. While they found some dizzying statistics about how adults are faring ― for example, 57 percent of people with a mental disorder did not receive proper treatment over the study period ― researchers were most alarmed by the findings surrounding youth mental health.

“I feel like it’s only something people have started to talk about in the last couple of years, if that,” Theresa Nguyen, vice president of policy and programs at Mental Health America, told HuffPost. “We’re starting to see data come out that shows not only are youth struggling significantly, but the numbers indicate ― like in our current report ― that the trend is getting worse.”

Mental Health America
The overall findings from the 2018 State of Mental Health Report published by Mental Health America.

How access to treatment is failing young people

Although access to services and insurance increased overall from last year’s report, researchers say there’s still not enough people receiving the care they need. This is especially true for teens: More than 76 percent of young people studied who had a major depressive episode ― which equated to approximately 1.7 million kids ― did not receive proper treatment for the issue.

Mental health treatment, whether it be therapy, medication or both, is the most effective way to manage a mental illness. Experts say that in extreme cases, treatment can also mean the difference between life and death.

“I wish I could say the mental health of our children is improving. Our report shows the opposite,” Paul Gionfriddo, president and CEO of Mental Health America, said in a statement. “Far too many young people are suffering ― often in silence. They are not receiving the treatment they need to live healthy and productive lives ― and too many simply don’t see a way out.”

What needs to be done

Experts say parents play a pivotal role in changing the conversation when it comes to their kids’ psychological well-being. Here are a few ways to spot if your kid is dealing with a mental health issue and how to realistically help them through it:

Look out for striking changes in behavior.

Nguyen says that drastic changes in mood ― especially in a month or a shorter period of time ― could be a sign that something bigger is at play. This can include withdrawing from social activities kids once loved, or displaying anger or sadness more than usual. Teens who might be engaging in self-harm may wear longer sleeves, even in warm weather, Nguyen added.

“That’s a huge red flag,” she said. “It’s kind of hard because these things correlate with puberty and sometimes adults are like, ‘Oh, my kid is just going through those shifts.’ It gets hard for parents because this period of time is so muddy.”

Talk about anything you notice.

Make your home an environment where teens feel comfortable approaching you about mental health issues, Nguyen said.

“Talking to your kid is really important,” she explained. “They’re really good at hiding problems … it’s really good for young kids, especially around puberty, to start having that conversation as you would with sex education.”

Let them know about any family history of mental health issues.

If you or a member of your family has experienced a mental illness, Nguyen says it’s vital that you bring it up with your kids. The more informed they are about their family history, the more likely young adults are to open up if they’re having issues of their own.

“As scary as it is, talking to kids about your own experience is a huge thing a parent can do,” Nguyen said. “Lead by example. Teenagers know a lot more than people give them credit for.”

Remind your child that mental health issues are nothing to feel shame over.

Bottom line: Mental illness deserves just as much attention and care as physical illness. Negative stereotypes surrounding mental health disorders only do more harm.

“It might help to think about [a] health perspective,” Nguyen said. “We wouldn’t be afraid to talk and hear about cancer or diabetes. Why are we afraid to share about mental illness?”

Read more: http://www.huffingtonpost.com/entry/youth-mental-health-report_us_5a0d02c4e4b0b17e5e13f4f4

Would You Trust a 3D-Printed Mini Organ to Test Your Drugs?

No one wanted to believe it, said molecular geneticist Hans Clevers.

In 2009, Clevers and his team had demonstrated an unusual new method of creating tiny, out-of-the-body replicas of human organs that could be used to study disease. These replicas were 3-dimensional organoids generated from human cells that perfectly replicated the structure of cells lining the intestine, and therefore could be studied and tested without using human volunteers.

(While it might seem as if this was a guaranteed winner in the books in terms of science innovation, Clevers and his team were rejected by several publications, before Nature finally published the report.)

Organoids could be a genius scientific workaround on a basic problem: How do we effectively, scientifically, but safely run experiments about humans? The little organs are poised to be a gamechanger in figuring out how cures to diseases could be derived. In fact, volunteers organoids can act as proxies that will stand in for them.

Testing new drugs and medical treatments is perilous, cumbersome, and time-consuming. More than 80 percent of new drugs tested in the U.S. to determine if they are safe for patient use fail during clinical trials because they prove to be ineffective. More than 30 percent are found to be toxic. There is an urgent need for improved systems to accurately predict the effects of drugs, chemicals, and biological agents on the human body, Anthony Atala, director of the Wake Forest Institute for Regenerative Medicine, said.

Which makes organoids seem like a lifesaver that can speed up and ensure the safety of the drug testing process. Innovations that generate organoids, in addition to bioprinting, include organ-on-a-chip technology and tissue-chips, which situate the organoid on a microchip.

In addition to generating organoids using bioprinters, other methods of creating organoids are being researched. Some organoids are created in lab dishes. Others use stem cells and other cellular materials to create organoids include placing tiny, testable organs on a microchip. These are called tissue-chips, which are not to be confused with organ-on-a-chip technologyboth use different combinations of humans cells and materials to create either miniature organs or tissues.

One limitation of testing drugs on organoids alone is that they are isolated from the nervous system and blood system, whereas the drug could impact the related processes. To address this, scientists are linking organs-on-a-chip together, so that they form a body-on-a-chip. In this way, they are joined together on chips just as they are joined together inside the human body.

The U.S. Food and Drug Administration has not yet approved any of these methods, but is reviewing them. The FDA partners with the National Center for Translational Sciences (NCATS), part of the National Institutes of Health, via NCATS Tissue Chip for Drug Screening program. Tissue chips are poised to deliver a paradigm shift in drug discovery, Dr. Danilo Tagle, associate director of Special Initiatives at NCATS/NIH explained in an email.

As organoid research moves ahead on many fronts, including stem cells, 3D bioprinting has proven to be cost-efficient. A pioneer in the field, Dr. Aleksander Skardal of the Wake Forest School of Medicines Institute for Regenerative Medicine, has observed, The liver and cardiac organoids that we bioprinted into tissue-on-a-chip constructs far surpassed the functionality of alternatives.

That 80 percent fail-rate of current testing demands something new. For one thing, animal rights proponents would welcome the end of clinical trials that dont involve running experiments on mammals.

Dr. Todd Evans is a professor of surgery and associate dean for research at New Yorks Weill Cornell Medicine. Evans and his colleagues have generated stem-cell-derived organoids from colon cancer, and a platform for testing drugs that block disease caused by patient-specific mutations.

Organoids represent a very important advance for modeling human disease, since they recapitulate at least to some extent the 3D architecture of an organ and thereby much better represent a tissue compared to standard 2D cell culture systems, Evans wrote to The Daily Beast in an email.

Evans has observed how its possible to screen pharmaceutical compounds for effectiveness as candidates for drugs, because organoids can mimic some aspects of cell biology. However, there are clearly limitations and these approaches will never replace clinical trials, Evans wrote. They are still an in vitro (in a laboratory) approach and do not take into account cross-organ communication or a multitude of human physiological and metabolic parameters. This might in the future be somewhat better achieved by organ-on-a-chip method.

Despite limitations, any method that ferrets out weaker drug candidates could save pharmaceutical companies, as well as taxpayers who fund the FDA, millions of dollars. Allevi, one of the pioneer research firms that developed bioprinters, designed a desktop bioprinter that measures 12 inches cubed and costs $10,000.

Other companies are jumping in. Pfizer Inc. is collaborating with Cambridge-based research firm Draper to develop liver, gastrointestinal, and other organ models. Colgate-Palmolive is another Draper partner, researching models of gum tissue for testing oral care products.

Use of organ models is much more predictive than using animals, Dr. Joseph Charest, Drapers Biomedical Solutions program manager and director of the Human Organ Initiative, told The Daily Beast in a phone interview.

What these models are able to do is recreate a disease state, Charest said. We can screen a lot of different drugs and compounds, in varying amounts, and we can do this fairly early in the pipeline, which allows you to rule out the bad ones and continue testing the good ones.

Draper develops multiple organs-on-chips. Weve been able to recreate the various organs that form the female reproductive system, and put them on chips. That is one example of how we connect organs, Charest said. The system has various pieces of tissue that communicate with each other.

Shortening the time required to get a drug to the clinic is really the point of all this science and research.

Heart-on-a-chip causes most live hearts to skip a beat. People are not going to get upset about making a pancreas, Stanford Universitys Bioethics Law professor Henry Greely told The Scientist in 2016. But the closer you come to making a human brain, the more issues get raised. Bodies-on-a-chip seem too Frankenstein-esque for some.

Nonetheless, plans include using human cells from several hundred, if not thousands of individuals, that represent the diverse demographics of the general population for use as surrogate clinical trials on chips, according to Tagle. Such platforms hold promise to reduce the cost and time it takes to bring drugs into market but also to minimize risk to patients.

Read more: https://www.thedailybeast.com/would-you-trust-a-3d-printed-mini-organ-to-test-your-drugs

Sylvester Stallone Denies Sexually Assaulting 16-Year-Old Fan In The ’80s

Sylvester Stallone denies he sexually assaulted a 16-year-old fan in his Las Vegas hotel room in the 1980s, according to TMZ.

The “Rocky” actor responded Thursday to allegations that he forced a minor to have group sex with him and his then-bodyguard at the Las Vegas Hilton hotel in 1986. The girl told police she was forced to perform oral sex on Stallone while the bodyguard had vaginal intercourse with her, according to a police report written at the time.

“This is a ridiculous, categorically false story,” a spokesman for Stallone told TMZ. “No one was ever aware of this story until it was published today, including Mr. Stallone. At no time was Mr. Stallone ever contacted by authorities or anyone else regarding this matter.”

Part of the story was originally made public last year when Doug Poppa, an ex-cop and reporter for the Baltimore Post-Examiner, obtained the police report and wrote about the incident. The allegations re-surfaced Thursday when The Daily Mail published a similar story and what appears to be a copy of the police report.

Representatives for both Stallone and the Las Vegas Metro Police Department did not immediately return HuffPost’s requests for comment.

This isn’t the first time Stallone has been accused of sexual assault. In 2001, a woman filed a lawsuit against the actor, alleging he “forcibly pinned” her against a wall and tore her clothes at a fitness center. In 2013, reports surfaced that he had paid off his late half-sister Toni-Ann Filiti to keep quiet about allegations that he had abused her for years. 

This is a developing story. Check back for updates.

NBC via Getty Images

Read more: http://www.huffingtonpost.com/entry/sylvester-stallone-sexual-assault_us_5a0da446e4b0b37054f4d9e1

These Are The Sexual Activities Most Likely To Cause Injury, According To Science

People do die having sex; if they don’t, they can get severely injured. This is something that’s notoriously difficult to categorize or rank, though.

The US Centers for Disease Control and Prevention (CDC) lets you see how many people in the US have died from “exposure to sunlight”, so it caters to vampires, but the closest we can find to sex-based injury appears to be the very ambiguous “overexertion from repetitive movements” and “exposure to vibration.”

Even the estimates for death via sex-induced heart attacks vary wildly. One places the number at around 11,000 victims in the US alone – mostly elderly men, it seems. Another suggests that the number is far lower, in the tens or hundreds of people per annum.

Ladies and gentlemen, this is nothing short of a logistical nightmare. The best we can do is rank sexual acts in terms of number of accidental injuries they are related to.

So, in ascending order – and leaving out some of the more (ahem) imaginative forms of reaching that naughty nirvana – here are the most inadvertently dangerous sex acts, according to science.

6 – Oral Sex

Again, this is difficult to verify, but there are very few studies or reported cases on accidental injuries as a result of oral sex.

You can imagine that there’s a fair few, of course – words like “blowjob” could be wildly misinterpreted – but whether it’s fellatio or cunnilingus, the risk of inadvertent injury is insignificant. You’re more likely to injure yourself if you engage in autofellatio, which has been known to cause a handful of spinal injuries.

Ick. Tetiana Volkonska/Shutterstock

5 – Use of Sex Toys or Objects

The problem with trying to rank this is that sex toys come in very different shapes, sizes, and types. There’s no single category for “injury via sex toy” in any scientific study we can find.

One analysis, in the journal Sexual Medicine Reviews, notes that “urethrovesical foreign bodies result mainly from sexual or autoeroticism practices and need individualized management.” This means that objects inserted into the urethra, which often cause considerable harm, are so diverse that each treatment is unique to the situation.

As there’s simply not enough data available, we’re going to make a reasonable assumption that this is more dangerous than oral sex, but not as risky as adventures involving an actual penis.

4 – Cowgirl

Yes, vaginal tearing is awful and does happen, but accidental injuries of this kind are rare. The vulva and vagina are relatively hardy – after all, babies are a lot more traumatic than penises are, in general, and they survive that.

The penis itself, however, is extremely prone to fracturing, and while uncommon, the incidence of this coitus-based catastrophe taking place is probably being underestimated. As noted by a study in the International Journal of Impotence Research, “some patients may be too embarrassed to seek medical attention from emergency rooms.”

Several studies have attempted to rank various sexual positions over the years, generally focusing on the risk of penile fracture, or PF. The aforementioned study, which came out just this year, found that in terms of surgically identified PF injuries, cowgirl was the least risky sexual position, accounting for 10 percent of cases.

3 – Masturbation (and general hand-to-genital contact)

Snap. jannoon028/Shutterstock

Masturbation is certainly one way to cause injury to the penis, particularly if it’s overzealous. Yes, if you get creative you may get something wedged into your vagina that can cause lacerations, but again, you can only bend a penis so far before you hear a terrible, gut-wrenching pop, followed often by a crimson fountain.

In this sense, “penile manipulation” – which, granted, also involves tucking in your tiny soldier into your trousers and other such tasks – accounts for 18 percent of all cases of PF, according to the same study.

Incidentally, according to the authors, in “Eastern countries, there is a higher incidence of cases associated with penile manipulation,” specifically the kind designed to force your willy to wilt.

“As many patients believe that the penis has a bone structure or cartilage, and that these are responsible for erections, they may try to manipulate their penises and make them snap – like fingers,” they note. Blimey.

2 – Missionary

The same study places missionary next, which leads to PF in 26 percent of cases. They suspect that, unlike any woman-on-top positions, the more frequently vigorous nature of the male-dominated sexual activity leads to a “great impact at the time of trauma” when the penis slips out for a brief moment.

1 – Doggy Style (in general)

Regardless of gender, and regardless of the, er, entry point, doggy style seems to result in the majority of PF, for the same reasons as described above. This study suggests it is responsible for 41 percent of all PFs.

At this point, a caveat is required. Another study from 2014, one that examined causes of PF using similar methods, came to very different conclusions.

Writing in the journal Advances in Urology, the team found that woman-on-top was the most dangerous (50 percent of PFs), followed by doggy style (29 percent). Penile manipulation was attributed to 14 percent of all PFs.

Unlike the more recent research, these academics argue that when the woman is on top, with her full weight on the penis, it’s harder to stop sex if an injury is about to occur.

In any case, it’s difficult to know which study is more accurate, but both rank doggy style quite highly. So, on average, it’s probably the most risky activity overall.

Risky business. Haoka/Shutterstock

Incidentally, in both studies, heterosexual intercourse appears to be far riskier in terms of PF than homosexual intercourse.

Heterosexual doggy style, for example, was 10 times more likely to result in PF than the homosexual equivalent, according to the 2017 study. The 2014 study reports that 10 percent of PF patients were homosexual, and 67 percent were heterosexual. Both studies involve small data sets, so it’s difficult to know how applicable to the wider world these figures are.

Bonus Round – Fisting

This is described by a review study in the Journal of Forensic and Legal Medicine as “an uncommon and potentially dangerous sexual practice,” one that is “usually a homosexual activity, but can also be a heterosexual or an autoerotic practice.”

Based on the findings of 14 separate peer-reviewed studies, external anal and/or genital trauma is observed in 22.2 percent of cases – a greater than one-in-five chance. Internal injuries, on the other hand, were found in the “totality” of patients. We’d argue, then, that this is the most dangerous and near-conventional sexual activity, because some form of injury will always occur.

This, of course, depends on whether you think damage to the vagina or rectum is worse than a penile fracture. Argue among yourselves.

Read more: http://www.iflscience.com/health-and-medicine/these-are-the-sexual-activities-most-likely-to-cause-injury-according-to-science/