Would You Trust a 3D-Printed Mini Organ to Test Your Drugs?

No one wanted to believe it, said molecular geneticist Hans Clevers.

In 2009, Clevers and his team had demonstrated an unusual new method of creating tiny, out-of-the-body replicas of human organs that could be used to study disease. These replicas were 3-dimensional organoids generated from human cells that perfectly replicated the structure of cells lining the intestine, and therefore could be studied and tested without using human volunteers.

(While it might seem as if this was a guaranteed winner in the books in terms of science innovation, Clevers and his team were rejected by several publications, before Nature finally published the report.)

Organoids could be a genius scientific workaround on a basic problem: How do we effectively, scientifically, but safely run experiments about humans? The little organs are poised to be a gamechanger in figuring out how cures to diseases could be derived. In fact, volunteers organoids can act as proxies that will stand in for them.

Testing new drugs and medical treatments is perilous, cumbersome, and time-consuming. More than 80 percent of new drugs tested in the U.S. to determine if they are safe for patient use fail during clinical trials because they prove to be ineffective. More than 30 percent are found to be toxic. There is an urgent need for improved systems to accurately predict the effects of drugs, chemicals, and biological agents on the human body, Anthony Atala, director of the Wake Forest Institute for Regenerative Medicine, said.

Which makes organoids seem like a lifesaver that can speed up and ensure the safety of the drug testing process. Innovations that generate organoids, in addition to bioprinting, include organ-on-a-chip technology and tissue-chips, which situate the organoid on a microchip.

In addition to generating organoids using bioprinters, other methods of creating organoids are being researched. Some organoids are created in lab dishes. Others use stem cells and other cellular materials to create organoids include placing tiny, testable organs on a microchip. These are called tissue-chips, which are not to be confused with organ-on-a-chip technologyboth use different combinations of humans cells and materials to create either miniature organs or tissues.

One limitation of testing drugs on organoids alone is that they are isolated from the nervous system and blood system, whereas the drug could impact the related processes. To address this, scientists are linking organs-on-a-chip together, so that they form a body-on-a-chip. In this way, they are joined together on chips just as they are joined together inside the human body.

The U.S. Food and Drug Administration has not yet approved any of these methods, but is reviewing them. The FDA partners with the National Center for Translational Sciences (NCATS), part of the National Institutes of Health, via NCATS Tissue Chip for Drug Screening program. Tissue chips are poised to deliver a paradigm shift in drug discovery, Dr. Danilo Tagle, associate director of Special Initiatives at NCATS/NIH explained in an email.

As organoid research moves ahead on many fronts, including stem cells, 3D bioprinting has proven to be cost-efficient. A pioneer in the field, Dr. Aleksander Skardal of the Wake Forest School of Medicines Institute for Regenerative Medicine, has observed, The liver and cardiac organoids that we bioprinted into tissue-on-a-chip constructs far surpassed the functionality of alternatives.

That 80 percent fail-rate of current testing demands something new. For one thing, animal rights proponents would welcome the end of clinical trials that dont involve running experiments on mammals.

Dr. Todd Evans is a professor of surgery and associate dean for research at New Yorks Weill Cornell Medicine. Evans and his colleagues have generated stem-cell-derived organoids from colon cancer, and a platform for testing drugs that block disease caused by patient-specific mutations.

Organoids represent a very important advance for modeling human disease, since they recapitulate at least to some extent the 3D architecture of an organ and thereby much better represent a tissue compared to standard 2D cell culture systems, Evans wrote to The Daily Beast in an email.

Evans has observed how its possible to screen pharmaceutical compounds for effectiveness as candidates for drugs, because organoids can mimic some aspects of cell biology. However, there are clearly limitations and these approaches will never replace clinical trials, Evans wrote. They are still an in vitro (in a laboratory) approach and do not take into account cross-organ communication or a multitude of human physiological and metabolic parameters. This might in the future be somewhat better achieved by organ-on-a-chip method.

Despite limitations, any method that ferrets out weaker drug candidates could save pharmaceutical companies, as well as taxpayers who fund the FDA, millions of dollars. Allevi, one of the pioneer research firms that developed bioprinters, designed a desktop bioprinter that measures 12 inches cubed and costs $10,000.

Other companies are jumping in. Pfizer Inc. is collaborating with Cambridge-based research firm Draper to develop liver, gastrointestinal, and other organ models. Colgate-Palmolive is another Draper partner, researching models of gum tissue for testing oral care products.

Use of organ models is much more predictive than using animals, Dr. Joseph Charest, Drapers Biomedical Solutions program manager and director of the Human Organ Initiative, told The Daily Beast in a phone interview.

What these models are able to do is recreate a disease state, Charest said. We can screen a lot of different drugs and compounds, in varying amounts, and we can do this fairly early in the pipeline, which allows you to rule out the bad ones and continue testing the good ones.

Draper develops multiple organs-on-chips. Weve been able to recreate the various organs that form the female reproductive system, and put them on chips. That is one example of how we connect organs, Charest said. The system has various pieces of tissue that communicate with each other.

Shortening the time required to get a drug to the clinic is really the point of all this science and research.

Heart-on-a-chip causes most live hearts to skip a beat. People are not going to get upset about making a pancreas, Stanford Universitys Bioethics Law professor Henry Greely told The Scientist in 2016. But the closer you come to making a human brain, the more issues get raised. Bodies-on-a-chip seem too Frankenstein-esque for some.

Nonetheless, plans include using human cells from several hundred, if not thousands of individuals, that represent the diverse demographics of the general population for use as surrogate clinical trials on chips, according to Tagle. Such platforms hold promise to reduce the cost and time it takes to bring drugs into market but also to minimize risk to patients.

Read more: https://www.thedailybeast.com/would-you-trust-a-3d-printed-mini-organ-to-test-your-drugs

The FDA has approved a blood sugar monitor that doesnt require a finger prick

Further proof the U.S. Food and Drug Administration has been warming up to modern technology — it has just approved the first continuous blood sugar monitor that doesn’t require the user to prick themselves over and over for a blood sample.

Today, the FDA cleared Abbot’s FreeStyle Libre Flash Glucose Monitoring System, a device that uses a small sensor wire inserted under the skin to determine glucose levels in adult diabetics. Another wand-like device is then waved over the sensor to measure and give a readout of those glucose levels.

This is a milestone move for the FDA as diabetes affects nearly 30 million people in the United States who currently have to test their blood sugar by pricking themselves several times throughout the day and every time they eat.

However, the idea for a prickless blood sugar monitor isn’t new. Tech companies have increasingly shown an interest in the massive diabetics market over the past few years. Apple is rumored to be working on such a device and its CEO Tim Cook has even been spotted wearing a possible prototype that could connect to the Apple Watch.

Other companies endeavor to build something similar, including Glucowise, which has a device still under development.

However, it seems it’s not so easy to create a needleless blood sugar detector. Google tried to build a contact lens that could detect glucose but it seems the project has gone nowhere since drug company Novartis licensed the tech in 2014. Another FDA-approved device for glucose monitoring without the prick called the GlucoWatch was approved in the early 2000’s, but consumers found it cumbersome and it happened to cause a bad rash in some.

But there’s new hope today that the Freestyle monitor has worked out all the kinks. The device is intended for those 18 and older and, after a 12-hour start-up period, can be worn for up to 10 days, according to a statement on the FDA’s website.

“The FDA is always interested in new technologies that can help make the care of people living with chronic conditions, such as diabetes, easier and more manageable,” said FDA spokesperson Donald St. Pierre. “This system allows people with diabetics to avoid the additional step of finger stick calibration, which can sometimes be painful, but still provides necessary information for treating their diabetes—with a wave of the mobile reader.”

Read more: https://techcrunch.com/2017/09/28/the-fda-has-approved-the-first-blood-sugar-monitor-that-doesnt-require-a-finger-prick/

You Lied Your Way Into A Job As A Surgeon! Can You Avoid Killing Anyone Long Enough To Collect Your First Paycheck?

Surgeons. The masters of the flesh. The gatekeepers of the organs. The doctors who get to shave patients.

These are the green-wearing gods who know that the human body is but a chessboard, and that the nipples are the king and queen, and the belly button is the opposing king or queen.

Today, finally, you are beginning your journey as one of them.

You have already gone through the arduous process of becoming a surgeon. After calling the hospital over and over every day for three weeks straight and praising Tylenol in the deepest voice you could muster to whoever picked up, being hung up on by countless doctors and nurses, you finally hit the big time.

Yesterday, you managed to get the chief of medicine on the line, who offered you a job after a mere 50 minutes of you bellowing to her about the white-and-red pill. Congratulations!

Okay. Being a surgeon is sweet as hell. You get to wear patients’ clothes around a hospital once the chemicals put them to sleep, you can eat as many tortilla chips as you want, and you can hide all of your favorite DVDs and family heirlooms inside toxic waste bins, the one place thieving pricks are too grossed out by to steal from.

Cool. But the best part of being a surgeon, bar none, is that incredible surgeon paycheck.

It’s no secret that surgeons are paid well, as every single day at 8 p.m., hardworking surgeons all over the world reap the fruits of their labor: a plastic bag filled with $600, given to them by their chief of medicine on their way out the door, in addition to a goodnight kiss on the forehead.

Exactly. So now that you’re a surgeon, you better do everything in your power to make it your $600 payday, because there is one universal stipulation that could jam you up: If a surgeon kills someone, everything completely goes to shit.

1) For starters, once a surgeon kills someone, they are NEVER allowed back in a hospital, ever. Even if you just want to go to hang out or to meet new lovers.

2) Your professional reference completely goes out the window. If a new job calls to ask about you, instead of a recommendation, the HR department hands the phone off to the absolute sickest pervert patient they have, and lets them air out whatever they’ve got kickin’ around up in their minds.

3) Lastly—and this one is the worst of all—you don’t get paid a dime, which would mean all of your efforts to become a surgeon were for NOTHING.

So, if you want to get to that sweet paycheck, you’re going to have to make it through one entire day as a surgeon without killing someone.

The hospital. The place where people come when they are bored to take off their pants and scream. This will be your new surgeon home, and today is your first day of work. As far as anyone inside is concerned, you are now a fully qualified surgeon, so if you want those 600 clams, you’re going to have to hold your own and stay off everyone’s radar.

“Please give me a surgery.”

Ah, shit. A sick kid is waiting for you right inside the lobby, and he looks all kinds of fucked up.

“I need a surgery pronto. I am dying, and it feels like none of my bones are connected to my other bones. I also have a rash that comes and goes. Please do surgery to me with your other doctor friends.”

“If you don’t give me a surgery right now, I will scream. I will scream so loud and for so long, and I will point at you the whole time. It will go on for so long that the rest of the doctors here will have no choice but to send you to jail.”

That was close. You’ve pissed your pants real good, and now you’re in the bathroom splashing your pants with water, the best way to clean pants that you’ve urinated in.

“You sure know your way around cleaning a pair of pissed pants, sport. Not bad at all.”

You look over and see that it’s the hospital’s janitor talking to you. He somehow opened the door in perfect silence while you were inside splashing your pants, and has been watching you for upwards of 90 full seconds.

“I’ve been watching you for upwards of 90 full seconds, and I can tell just by looking at you, you’re no surgeon.”

“Easy, easy. I’m not gonna rat you out. I’m gonna help you.

I take it that you’re in here lying to be a surgeon, hoping to get ‘The $600 Bag Treatment,’ huh? Well, you’ve got a friend in me. I’ve seen it before, and I’ll see it again. All you gotta do is make it until 8 p.m. without killing a soul and you’re in the clear. So whadya say you come lay low with me for the rest of the day, spend some time hanging with a new bud so you don’t end up killin’ no one before you get that money?”

“I, uh, how do you mean?” he says, visibly becoming self-conscious about the entire interaction so far. “I’m just tired today, so if I’m acting weird, that’s what that’s about, probably. Allergies are being weird, too.”

“Follow me!” the janitor says before sprinting down the hallway. You do your best to keep up with him as he weaves in and out of patients and doctors before you finally arrive at a huge metal door. He slides open the rusty door to reveal a set of long, winding stairs that lead to a dark, desolate basement, and turns to you with a half smile.

“It’s not delivery, it’s DiGiorno,” he says before letting out a quick, uncertain laugh, looking over his shoulder at you to kind of check in and see if you’re laughing or anything at what must have been some sort of joke.

“That was dumb, never mind,” the janitor says, shaking his head as his shoulders slump, trying to explain his joke before slowly progressing into full-blown self-deprecation. “I was thinking, like, how in the old commercials, I’d be the delivery guy and you’re the pizza—I don’t know, forget it. It was dumb. Sorry.”

You follow the janitor down the stairs and into the basement of the hospital, and lo and behold, it’s a full-blown bachelor’s pad! The janitor has stocked the place with some of the best things: a ping-pong table, a “Forever 27” poster, an old-timey popcorn machine, and a bunch of orange pill bottles filled with Frosted Cheerios.

“This is my chill zone. I’m down here almost all the time, which is why the hospital is filthy and patients always seem to get sick immediately after they get better.”

“We got all day, brother, so we could either sit down and talk about that important-looking guitar I have mounted on the wall over there, or we could stand near the stairs and wonder if Slash has ever signed a guitar and sold it for $20,000 online before, or maybe we could lay down on the ground and trade stories about the most expensive thing we’ve ever mounted on a wall. Your call.”

“I can’t lift my arms above my waist because of a power-washer accident.”

“You got a good eye, kid,” he says as though you brought it up completely unprompted, proudly looking up at the guitar he somehow mounted unnecessarily high on his wall.

“Believe it or not, Slash signed that guitar, and I was lucky enough to spend all of the money I have on it. I usually don’t do this for anyone, but for you, I’ll climb all the way up there and get it if you want to hold it.”

“I’d climb anywhere for one of my boys.”

“I’ll put a very wet towel over them. I’m sure that will be fine.”

You’ve killed! You’ve killed!

You put the janitor in grave danger by selfishly asking him to grab his Slash guitar off the wall. After the janitor put a soaking-wet towel on top of his countless basement wires in order to walk over to the wall and begin his climb, he was immediately electrocuted and fell crashing to the ground without the ability to raise his arms and break his fall. It’s unclear if it was the electricity surging through his body that did him in, or if it was the way his neck snapped on a nearby stool because of the horrible, unnatural way he fell. But either way, he is definitely dead, and it is your fault.

You’re no longer a surgeon, and you can kiss that bag of $600 goodbye.

As you go back up the stairs and start heading toward the lobby, you can hear that he starts to follow you, but then locks himself in the bathroom you were in earlier and begins screaming at himself in the mirror for messing up what could’ve been a nice day. His screaming gets louder and louder before it comes to a halt after you hear the sound of him snapping his mop over his knee in fury.

“I need you to give me a surgery right now.”

Ah, damn. It’s the sick kid from earlier.

“I feel like I’m on a boat at all hours of the day, and my elbows are dry. I need you to cut me open and drain me out, if that’s what it takes, and to please get me home by later today.”

You pick the kid up, throw him over your shoulder, and walk through the hospital looking for a good room to cut him open in. After 20 minutes, you finally find the room with all of the surgeons in it, and you slam the kid down on the empty table they’re all staring at.

Now all eyes are on you. You’re going to have to step up and say something pretty incredible to get all of these surgeons on your side.

You’ve killed! You’ve killed!

After you said that ridiculous, dumbass comment, every surgeon in the room became furious at you and began hammering you with questions about your qualifications. You tried mumbling through more Tylenol facts, which went much worse in person than it did on the phone, and somewhere during your 25-minute verbal beatdown from the other surgeons, the kid died on the table.

You are no longer a surgeon, and you will never get a plastic bag filled with $600.

Share Your Results

Everyone starts nodding and smiling and patting each other on the back. Good shit.

“Ha, nice,” a woman says, whose voice you recognize from the phone as the chief of medicine at the hospital. She quickly anesthetizes the patient to finally stop him from grabbing and clawing at everyone’s surgical masks, and within seconds the little spaz is sleeping.

At that moment, the tallest doctor you’ve ever seen walks into the door wearing a backwards hat and confidently drinking Barq’s Root Beer out of a 2-liter bottle.

“I’ve never seen you around here,” he says after putting the root beer down firmly into the lap of the unconscious kid and eyeing you up and down suspiciously. “Enlighten us, fresh meat. Now, what surgery are we performing on this little man, exactly?”

Ah, this guy is onto you. Need something big here to throw everyone off your tracks.

“Doctors, you two can be mean to each other in the parking lot all day long if you want to, but that’ll be enough fighting in my hospital,” says the chief of medicine after banging her fist down onto the kid’s chest like a gavel to get everyone’s attention.

“This little boy is in dire need of a heart transplant. We need to start immediately.”

“Doctors, that’ll be enough talk about whether or not there are actually types of surgeries or not, because there simply is not a correct answer,” says the chief of medicine after banging her fist down onto the kid’s chest like a gavel to get everyone’s attention.

“This little boy is in dire need of a heart transplant. We need to start immediately.”

“Doctors, please stop winking at each other,” says the chief of medicine after banging her fist down onto the kid’s chest like a gavel to get everyone’s attention.

“This little boy is in dire need of a heart transplant. We need to start immediately.”

After noticing that no one is reacting to you pissing yourself, you look around and realize that every surgeon in the room has also already pissed themselves. Then you remember that surgeons are constantly pissing themselves during surgery, like bicyclists during races, for reasons completely unknown.

The chief of medicine takes out a toolbox from underneath the surgery-room sink and hands each surgeon a tool. She takes each tool out one by one and starts passing them down the line. One doctor gets a small shovel, one gets a large knife, another gets a pickax, and on and on it goes, until you finally end up with the flashlight!

“Um, yeah, that’s my flashlight, pal. I’m always the flashlight man around here,” says the root-beer doctor.

“No,” interjects the chief. “New guy can hold the flashlight today. I have a good feeling about this.”

Your new rival is stunned. He shoots you a dirty look, threateningly crosses his thumb over his neck, and then does it again with his other thumb, but slower. Then he quietly mouths something that you didn’t really get a good read on, but from what you did see, your best guess is that he was saying something like “Fracking mountains,” or “Simply delicious.” Then he is handed the worst tool: the blood napkin, the tool that wipes up all the loose goo and pus.

“Ah, c’mon, man. Quit it. What the hell.”

The surgery is now well under way. The chief is slicing and dicing and moving parts around left and right. It’s pretty much a one-woman show.

Most of the other doctors are using their tools just to kind of scrape some bones and stuff when they feel like they should get in the mix, usually after not doing anything for a couple minutes straight and getting nervous that someone will notice how they’re not really that crucial to the operation.

You’re getting bored by the whole thing at this point, but at least you’re holding your own with these docs and, most importantly, haven’t killed anyone yet.

Surgery still going. Getting kind of repetitive. A couple doctors shuffled out for a minute and came back with crackers, but the crackers are all gone now. You didn’t even notice they had crackers until there were only, like, four left in the sleeve, so at that point, asking for some really wouldn’t have been cool.

Surgery is getting boring.

Surgery is boring as hell.Your arms got tired from holding the flashlight up, so you put it down for a minute and no one seemed to notice. You’re back up now.

Kid woke up and started screaming LOUD, but now he’s sleeping again.

“You were scared!” “No, you were scared!” “I wasn’t scared, you were scared!” The surgeons are all ragging on each other and having fun again. Finally got some juice in the room. Whole crew got a good laugh out of that one.

Woah, wait a minute. Oh, man. You see something inside the kid’s body. Wedged deep in between his rib cage and his liver, there looks to be something shining and throbbing, and you’re pretty sure you’re the only one who sees it.

Two doctors broke away from the surgery about 15 minutes ago to arm wrestle on a nearby stool, and the rest of the surgeons have all one-by-one walked over to form a circle around them so they can gamble. Meanwhile, the chief is still hacking away at this kid’s organs with all of her might, and seems way too dialed-in to notice the game changer you’ve found.

You’ve killed! You’ve killed!

You thought you were being a hero by yanking out what you thought were some sort of wet, shining metals, but were actually the poor kid’s veins. You are no longer a surgeon, and can go ahead and kiss that sweet paycheck goodbye.

“Those are veins. They are not ‘evil copper and metals sticking out of this poor bastard’s guts.’ Do not call them that.”

Damn. Misread that one. The chief is totally onto you now.

“But I appreciate you speaking your mind when you think something is amiss,” she continues, looking up and making eye contact with you for the first time. “That takes a commitment to the job that some of my other doctors lack at times,” she says, motioning to the doctors across the room who are now attempting to disguise their arm-wrestling gambling ring by draping a hospital gown over the two meaty, dueling arms.

The chief reciprocates your unblinking eye contact and begins nodding in perfect unison with your nodding. This goes on for a good 20 seconds or so, the grunts of the two arm wrestlers and the slaps of cold, hard cash hitting the tile becoming the only sounds in the room.

At that moment, you and the chief simultaneously feel a romantic charge between you, and it feels beautiful and right. But that romantic feeling is immediately followed by a simultaneous paternal feeling, but it’s unclear who is the parent and who is the child. Then the two feelings of physical attraction and familial protectiveness fuse together into one singular emotion, and it feels disgusting to both of you.

“Yeah, yeah, go catch up with them. I’ll hold it down over here, cool,” the chief kind of half-mutters to herself and to you while shaking her head and getting back to surgery.

You walk over to the gambling circle and see the two exhausted surgeons pulling and pushing as hard as they can to win. The two doctors are so evenly matched that their arms aren’t moving or shaking in the slightest. If it weren’t for the veins about to explode out of their temples and the tears streaming down their faces, you’d have no idea how intense the duel was.

All of the other surgeons are quietly going apeshit. Almost all of them are either gently pounding their chests, gingerly slapping the ground, or shaking their fists in the air, all the while whispering bad arm-wrestling advice like “Win the skin!” or “Make him smooth!”

It’s definitely a pretty sweet scene, and you decide that you want to get in the mix.

As you go to ask the doctor next to you, your rival doctor steps in front and interrupts:

“Looking to get in on the action but lacking the funds, newbie? Don’t worry, fresh meat. I got you covered. Also, we’re rival doctors, just in case that wasn’t clear.”

Whoa, pretty cool to get a rival doctor on your first day on the job. That probably usually takes years.

“That’s my coat over there,” he says, pointing to a white lab coat being worn by one of the arm-wrestling surgeons. “Go ahead and take my wallet out of the pocket and take out as much money as you want.”

He then lets out a weird little laugh and looks around to see if anyone else is laughing. One other doctor did laugh, but he’s in the middle of a conversation with another surgeon, so you’re pretty sure the laugh had nothing to do with your rival.

“I have coats all over this hospital that you wouldn’t know a thing about,” he says, raising his fist up to your chin real quick, trying to get you to flinch. You stand your ground and don’t flinch at all, though, and he sheepishly brings his fist back down to his side.

You’ve killed! You’ve killed!

In a brilliantly executed scheme, your rival tricked you into reaching into the coat of one of the doctors who is arm wrestling. When the arm wrestler saw you trying to steal his wallet, his mix of adrenaline and dangerously high blood pressure caused his heart to explode.

Your misconduct has resulted in a death, meaning you can no longer be a surgeon, and you will never see that sweet, sweet bag o’ cash.

The Pill and Libido (Sexual Health for Women)





 

1 2 5
What Is The Chinese
Secret To Optimum
Blood Pressure?
Why This Is The
Healthiest Oil On Earth?
Click To Learn More
100% of Your
Vital Nutrition In
Just 30 Seconds

For 40% of women, the Pill works in an unexpected new way: By making you NOT WANT to have sex!

Trying to figure out why she won't sleep with you? CHECK OUT:

The Miracle Cure Gwyneth Paltrow Accidentally Got Right

Gwyneth Paltrow, Oscar-winner and dubious lifestyle guru, is under fire again. At issue this time: Body Vibes, the small stickers that can be placed on the upper arms to promote healing, rebalance energy frequencies, smooth out physical tension and anxiety, and boost cell turnover.

Paltrow wasnt criticized because her website Goop was again peddling a product that couldnt prove any of its claims or outright dangerous. Or because oneboosting cell turnoversounded like something that no one should ever want. Rather she was slapped for the biological basis on which these claims were made: Paltrow said the healing power of Body Vibes came from NASA space science. Its inventors had supposedly used the same conductive carbon material that NASA uses to line space suits so they can monitor an astronauts vital [signs] during wear. According to GOOP, the technology developed by NASA used a biofrequency that resonates with the bodys natural energy field.

NASA immediately debunked Paltrows claim, stating that spacesuits do not have any conductive carbon material lining. (And Goop subsequently removed it.)

Although many have been quick to dismiss Goops latest miracle cure, Body Vibe stickers do offer the same thing that alternative healers typically promisea chance to benefit from the placebo response.

One of the first demonstrations of the power of the placebo took place on the battlefields of World War II, where a nurse ran out of morphine. Unable to tell a wounded soldier that she had nothing to treat his pain, she said the saltwater she had just given him was actually morphine. To her surprise, the soldiers pain disappeared. Researchers have since found that people can learn to release their own endorphins: powerful, morphine-like, pain-relieving chemicals made by the pituitary gland and hypothalamus. Indeed, the biological basis of pain relief from acupuncture has nothing to do with where the healer puts the needlesor even whether the needles enter the skinand everything to do with some patients releasing their own endorphins.

The placebo response isnt limited to pain relief.

In 1957, John Imboden and colleagues at Johns Hopkins School of Medicine performed a landmark experiment. They administered a series of psychological tests to military personnel working at Fort Detrick, Maryland. A few months later, an influenza pandemic swept across the camp. Imboden found that recruits who were depressed had symptoms of influenza that lasted longer and were more severe than those in recruits who werent depressed. In other words, mood determined illness. The mind, wrote John Milton in Paradise Lost, can make a heaven of hell and a hell of heaven.

In 1975, Robert Ader and Nicholas Cohen from the University of Rochester School of Medicine took Imbodens observations one step further. They found that rats given cyclophosphamide (an immune-suppressive drug) in saccharin-flavored water developed an inability to respond to foreign proteins. Weeks later, their immune systems recovered. That wasnt surprising. What was surprising was that when these same rats were later given saccharin-flavored water only, they again had a lesser immune response. The rats, by pairing the taste of saccharin with an immune-suppressive drug, had learned to suppress their own immune systems. Amazing.

The next question: Could researchers teach people to suppress their immune response? Again, Robert Ader took the lead. Working with a teenager with the autoimmune disease lupus, he paired cyclophosphamide with a distinct taste (cod liver oil) and smell (rose perfume). Like the rats, the boy learned to suppress his immune response, requiring less-frequent dosing of the steroid necessary to control his disease. Other researchers replicated Aders findings. And it worked both ways; not only could people learn to suppress their immune responses, they could learn to enhance them.

Which brings us back to Gwyneth Paltrows Body Vibes. If people believe that Body Vibe patches are giving them more energy or relieving tension, whos to say that this belief cant result in healing? If people can learn to release their own endorphins or up-regulate or down-regulate their own immune systems, why cant Body Vibe patches offer some benefit? And, unlike antidepressants or mood-elevating drugs, these patches have no side effects.

Another thing. Although the cost of Body Vibe patches$60 for a pack of 10is no doubt logarithmically greater than the cost of manufacture, according to the theory of cognitive dissonance, the more expensive the better. This concept was first tested at a racetrack in the 1960s. Researchers asked bettors to rate their horse as they walked toward or away from the betting window. Bettors faced two conflicting facts: 1) Any horse could win the race, 2) I bet a lot of money on only one horse. To resolve the conflict, bettors rated their horse much higher after placing their bets. (Heres that study.) In another, researchers from MIT tested the capacity of two sugar pills to relieve pain. One group was told that the pill cost 10 cents, the other that it cost $2.50. Participants experienced less pain with the pill that was said to be more expensive.

But is it ethical for Body Vibes marketers to deceive?

In fairness, all practitionersmainstream or otherwiseemploy some form of deception. They know that a positive attitude, reassuring demeanor, and air of competence are important. We use the placebo effect all the time, says Art Caplan, professor of bioethics at New York Universitys Langone Medical Center. Ive got a bowtie. I wear a white coat. You come to a big building that looks pretty impressive. I expect someday to see billboards go up in cities that say we have a really big machine and it makes a lot of noise and we dont know how it works but you can only get it from us so come on down.

Indeed, it would be more honest if mainstream doctors walked into a patients room and said, Look, we will definitely know more about how to treat your illness a hundred years from now. Frankly, I suspect doctors in the future will look back on some of the things that were doing today and laugh. Although our understanding of many diseases is excellent, for some were just treading water, and for others were completely lost. No clinicians (in their right mind) say this. From the days of shamans and witch doctors to the modern-day physician, everybody has their props, their deceptions. In fact, studies have shown that when physicians claim that one particular medicine will be more effective, the patient will later perceive that medicine as being more effective.

The line that cannot be crossed, however, is recommending placebo therapies that are potentially harmful. Unfortunately, in several instances, Goop has crossed that line, including touting vaginal steaming with mugwort to balance female hormone levels and cleanse the uterus, which, apart from the fact that mugwort isnt a hormone and vaginal steam (absent pressure) will never reach the uterus, could cause burns or bacterial infections. Or promoting placing $66 jade eggs the size of golf balls in the vagina in hopes of boosting orgasms, enhancing kidney strength, improving physical appearance, and increasing vaginal tone, hormonal balance, and feminine energyas well as the risk of bacterial infections, including toxic-shock syndrome. Or even cleansing the colon with enemas to remove toxins, boost energy, and enhance the immune system. These have no proven benefit in otherwise healthy people, and can cause dehydration, infections, vomiting, and, worst of all, bowel perforations.

Although Gwyneth Paltrow should be held accountable for therapies that are potentially dangerous, Body Vibe patches dont fall into that category. And Paltrow could reasonably argue that believing that you are benefiting from the patches might trigger a physiological response that is actually beneficial. Belief is a powerful medicine.

Paul A. Offit is the director of the Vaccine Education Center at the Childrens Hospital of Philadelphia and the author of Do You Believe in Magic? The Sense and Nonsense of Alternative Medicine (HarperCollins, 2013).

Read more: http://www.thedailybeast.com/the-miracle-cure-gwyneth-paltrow-accidentally-got-right

Birth control app Nurx now delivers to the contraceptive deserts of Texas

About half the counties in Texas dont have the number of public clinics required to meet the contraceptive needs of the population. So Nurx, an at-home birth control delivery app, decided to give women in the state the option to get birth control whenever they want and without ever needing to step into a clinic or even physically see a doctor.

Starting today, those in the Lone Star State will be able to tap the Nurx app and get contraceptives delivered straight to their door.

While Texas isnt the only state with a giant contraceptive desert, or an area withoutat least 1 clinic to every 1,000 women in need of publicly funded contraception, it is certainly the biggest area of land in the United States not meeting these needs.

And with Trumpcare looming, and Trumps recent Religious Freedom order, which allows businesses to deny birth control coverage based on religious reasons, many women could lose access to their publicly funded birth control pills and even more publicly funded clinics could go under, leaving a large and vulnerable population wide open to other, possibly dangerous methods of preventing birth.

While there are plenty of birth control delivery services out on the market, such as Maven, The Pill Club, Lemonaid and BirthControlBuzz, I had a hard time finding any that delivered in Texas (get at me if you do). Thats not to say they wont at some point, as each of them could easily open up shop in this area, but it does seem Nurx,which is not a free birth control delivery service, but does provide the pills at a reasonable cost, may havediscovered a goldmine of people in need, for the time being.

For instance, a little more than half of all pregnancies in Texas were unplannedin 2015, costing taxpayers $2.9 billion that year. However, according to a Guttmacher Institute report, the total gross public savings from preventing unintended pregnancies would have been $2.14 billion if women and couples could be empowered to prevent them. Couple that with the teen birth rate in Texas, which sharply declined by 56 percent over the last two decades, thanks in large part to contraceptives, according to the National Campaign to Prevent Teen and Unplanned Pregnancy.

Couple that with an additional estimate of more than 19 million women living in these contraceptive deserts nationwide and its easy to see adding these types of services could save money at the state level by removing middlemen and increasing access, as well as provide a lucrative area for Nurx and other birth control delivery apps to tap.

Read more: https://techcrunch.com/2017/06/05/birth-control-app-nurx-now-delivers-to-the-contraceptive-deserts-of-texas/

Prevention of Cervical Cancer- Natural Medicine

If You’re Experiencing recurring vaginal itching, vaginal infection, foul Vaginal Discharge & Vaginal Irritation, READ THIS IMMEDIATELY…

Discover The Rare Leaves From South East Asia Jungle Help Get Rid of Vaginal Itching, Fishy Discharge, Yeast Infection and Bacterial Vaginosis Within Days…”

smeall vaginal 3

Click Here To Learn More!

1 2 3
What Is The Chinese
Secret To Optimum
Blood Pressure?
Why This Is The
Healthiest Oil On Earth?
Click To Learn More
Bring Your Old
Battery Back To Life!
4 5 6
How To Survive In
Bed & Nail Women
Like A Rockstar!
100% of Your
Vital Nutrition In
Just 30 Seconds
How A 2000-Year-Old
Nepalese Secret To Cure
Your Sciatica in 7
DAYS OR LESS

Dr. Barrett discusses dietary and lifestyle interventions to help prevent cervical cancer.

Uthman on Cervical Cancer

If You’re Experiencing recurring vaginal itching, vaginal infection, foul Vaginal Discharge & Vaginal Irritation, READ THIS IMMEDIATELY…

Discover The Rare Leaves From South East Asia Jungle Help Get Rid of Vaginal Itching, Fishy Discharge, Yeast Infection and Bacterial Vaginosis Within Days…”

smeall vaginal 3

Click Here To Learn More!

1 2 3
What Is The Chinese
Secret To Optimum
Blood Pressure?
Why This Is The
Healthiest Oil On Earth?
Click To Learn More
Bring Your Old
Battery Back To Life!
4 5 6
How To Survive In
Bed & Nail Women
Like A Rockstar!
100% of Your
Vital Nutrition In
Just 30 Seconds
How A 2000-Year-Old
Nepalese Secret To Cure
Your Sciatica in 7
DAYS OR LESS

Pathologist Ed Uthman, MD, in a short interview about preventing cancer of the cervix. Produced by Stafford Weekly News.

Vaginal Womb Detox Herbal Tampons For Women It Works

If You’re Experiencing recurring vaginal itching, vaginal infection, foul Vaginal Discharge & Vaginal Irritation, READ THIS IMMEDIATELY…

Discover The Rare Leaves From South East Asia Jungle Help Get Rid of Vaginal Itching, Fishy Discharge, Yeast Infection and Bacterial Vaginosis Within Days…”

smeall vaginal 3

Click Here To Learn More!

1 2 3
What Is The Chinese
Secret To Optimum
Blood Pressure?
Why This Is The
Healthiest Oil On Earth?
Click To Learn More
Bring Your Old
Battery Back To Life!
4 5 6
How To Survive In
Bed & Nail Women
Like A Rockstar!
100% of Your
Vital Nutrition In
Just 30 Seconds
How A 2000-Year-Old
Nepalese Secret To Cure
Your Sciatica in 7
DAYS OR LESS

Vaginal Womb Detox Herbal Tampons For Women It Works. Product Name: Vaginal Detox Herbal Tampons For Women
Tampons are manufactured in the most sterile environment that has been approved by the "GMP" standard (quality standard). They do not contain any chemical additives and have passed more than 1000 clinical trials that confirmed the safety of the ingredients – no side effects and are absolutely non-toxic.
Main Ingredients:
Refined from Osthol, Stemona sessilifolia (Miq.)Miq, Kochiascoparia, motherwort,Rhizoma smilacis glabrae,Angelica,Rhizoma chuianxiong and borneol.
Healthy Function:
These ingredients regulate the function of endocrine gland secretion, normalize blood circulation, improve facial skin complexion/wrinkles/hyper-pigmentation. They also treat the following gynecological ailments: endometriosis, cervical erosion and dysplasia, pelvic inflammatory disease.
Main changes after using tampons
Step 1 :Generally,the tampon will be pulled out from vagina after 3 days later. you can see that the tampon is bigger than before.it adsorpts lots of toxins from vagina, vaginal itching, pain, odor and other gynecological symptoms were relieved.
Step 2 : erosion, thick secretions and bacteria adsorbed on the tampon were discharged continuously.urinary frequency,urgency were disappear gradually,leucorrhea was reduced and the odor disappeared.
Step 3: enhance the vaginal tissue metabolism,fast the healing of the vaginal and uterine wound caused by childbirth,abortion,becomes smooth to restore the women’s vagina.
Step 4: ovarian androgen secretion of hormones return to normal levels, regulating qi and blood, balance the endocrine,
Suitable to the people:
1.Abnormal vaginal discharge(Leucorrhea),vagina itching,Irregular menstruation,Menstrual pain,
2.Endometritis,cervical erosion,annex inflammation,vagintis,pelvic inflammatory,yeast infection and other kinds of gynecological diseases.
3. ovarian cysts,uterine fibroids and other uertus disease
4. Melasma,dark spots,bad sexual life.
Specifications: 1g each tampon
Directions:
1. Wash your hands and open the foil bag containing one tampon
2. Pull out the string of the tampon;
3. Insert the tampon inside vagina approximately 7 cm deep;
4. You must remove the tampon 3 days later;
5. Clean vagina with warm water
6. Insert next tampon 24 hours later after removing the first one;
7. Used for healthcare for the perineum;
Warning:
1. Do not use tampons 7 days before the onset of menstruation and wait at least 3 days after your last day of menstruation before using a tampon
2. Do not use tampons during menstruation, or if you are pregnant or if you are a virgin
Avoid using tampons, if you are allergic to any ingredients of the tampon (see the ingredient listing above)
3. You may soak the tampon in a glass of water and use the liquid for douching.
medical daily, medicaldaily.com, health news, medical news, medical science, medicine, drugs, treatment, disease

Homemade Vaginal Wash

If You’re Experiencing recurring vaginal itching, vaginal infection, foul Vaginal Discharge & Vaginal Irritation, READ THIS IMMEDIATELY…

Discover The Rare Leaves From South East Asia Jungle Help Get Rid of Vaginal Itching, Fishy Discharge, Yeast Infection and Bacterial Vaginosis Within Days…”

smeall vaginal 3

Click Here To Learn More!

1 2 3
What Is The Chinese
Secret To Optimum
Blood Pressure?
Why This Is The
Healthiest Oil On Earth?
Click To Learn More
Bring Your Old
Battery Back To Life!
4 5 6
How To Survive In
Bed & Nail Women
Like A Rockstar!
100% of Your
Vital Nutrition In
Just 30 Seconds
How A 2000-Year-Old
Nepalese Secret To Cure
Your Sciatica in 7
DAYS OR LESS

Don't forget to check out our brand new website –

Commercial vaginal washes contain harsh chemicals & synthetic fragrances that can lead to break outs & irritation in the vaginal area. Watch how you can make ♥vaginal wash ♥ using natural ingredients available in your kitchen! Click here to subscribe – . Check other awesome ♥♥♥ORGANIC MAKEUP♥♥♥ videos:

A. BASE CONCEALER :
B. SKIN MOISTURIZER :
C. BLUSH :

Also, check our food therapy channel:

—————————–

Homemade Vaginal Wash

• Commercial vaginal washes may cause irritation
• Natural antibiotics within the vagina protect it from infections.A
natural wash helps maintain the balance of these antibiotics

Natural vaginal cleaner:

• Keeps vagina odor free
• Is non toxic
• Prevents rashes or irritation

Homemade vaginal wash using aloe vera:

Aloe vera has strong anti-fungal & anti-septic properties & helps to get rid of the organisms that contribute to infections

1. Add ½ cup of water in a bowl
2. Slice open an aloe vera leaf & scrape the gel out of it
3. Mix the gel with the water
4. Apply this on your vagina
5. You can then rinse it with warm water

Homemade vaginal wash using white vinegar:

White vinegar is antibacterial in nature & also has the power to neutralize odor

1. Add ½ cup of water in a bowl
2. Mix 1 tbsp of white vinegar in it
3. Pour it onto your vagina
4. Rinse it out with water

Tips:

• Always wipe and clean your anal area front to back
• Choose loose cotton underwear
• Wash your vagina with warm water 4-5 times a day
• Drink lots of water

—————————–

SUBSCRIBE TO HOMEVEDA:

JOIN US ON FACEBOOK:

FOLLOW US ON TWITTER:

These remedies are based on the principles of Ayurveda, the ancient Indian science of healing, and are completely natural, non-invasive, and can be prepared at home. Consult your doctor if the symptoms persist. Refer to the terms of use on our website